Our previous study reported that the nuclear factor kappa B (NF‐κB) signalling pathway play a vital role in regulating the inflammatory response and that MD1 has an effect on NF‐κB suppression in the setting of obesity.18 Therefore, the NF‐κB signalling pathway was investigated to confirm MD1 function after aldosterone infusion. The gene discussed is LY86; the disease is obesity due to melanocortin 4 receptor deficiency.