However, Tian et al demonstrated in vivo a reduction in STAT3 phosphorylation in mice with AOM/DSS‐induced colon tumors following aspirin treatment.42 Thus, low‐dose aspirin might lead, by a reduced secretion of pro‐inflammatory cytokines, to a modulation of the IL6‐STAT3 signaling pathway resulting in suppression of oncogenesis in the inflammation‐associated AOM/DSS model. This evidence concerns the gene STAT3 and colonic neoplasm.