NME1 and hepatocellular carcinoma: Murine experiments by Boissan et al [66] proved the anti-metastatic effect of NM23-M1 as follows: crossing of transgenic mice prone to hepatocellular carcinoma (ASV mice expressing the SV 40 large T antigen in the liver leading to hepatocellular carcinoma), into an NM23-M1 knockout strain, resulted in double transgenic mice showing a higher incidence of lung metastases compared to the original single mutants.