CD8A and multiple system atrophy: Similarly, there was a significant 1.95-fold increase of CD8+ T cells/mm3 in the putamen (Control 2055 ± 386.1, MSA: 4010 ± 464.1, p = 0.0159) and a 2.83-fold increase (Control: 1,660 ± 296.4; MSA: 4,702 ± 585.4, p = 0.0079) in the substantia nigra of MSA cases compared to controls (Fig. 2c).