Nevertheless, using Tcrb−/− and Cd4−/− mice, we expanded our findings to show that these infiltrating T cells, and more specifically Tbet+, IFN-γ producing Th1 CD4 T cells (Fig. 7), are involved in mediating not only the CNS myeloid response to Olig001 SYN (Fig. 4), but also the demyelination associated with this model of MSA (Fig. 7). The gene discussed is CD4; the disease is multiple system atrophy.