INS and Hyperglycemia: The research indicates: 1) that serum NP levels tend to be higher in diabetic patients, 2) NP may inhibit the expression of PPAR-γ by itself or jointly with other substances, which in turn interferes with the ability of insulin to regulate blood glucose, 3) NP promotes overexpression of SREBP-1c to impair the metabolic regulation of fatty acids and glucose, which causes hyperglycemia, and 4) no correlation was detected between Wnt5a and NP.