Regulated by multiple hormones and nutrients, such as insulin, leptin, glucagon, and liver X activated receptor, SREBP-1c mediates insulin-based regulation of the expression of several genes, while it participates in B cell dysfunction genes is and development, and plays a vital role in the pathogenesis of insulin resistance, obesity, and T2D. The gene discussed is INS; the disease is obesity due to melanocortin 4 receptor deficiency.