Phosphorylation of PRAS40-Thr 246 could also mediate abnormal renal lipid metabolism of diabetes mellitus (17) known as a common characteristic of tumor cells (18, 19), but the relationship between p-PRAS40-Thr246 and abnormal renal lipid metabolism of tumor cells has not been confirmed yet. The gene discussed is AKT1S1; the disease is diabetes mellitus.