The levels of p-PRAS40-Thr246, PI3K and AKT in gastric cancer cells of the three groups were all included in the Pearson correlation analysis, and the results showed that p-PRAS40-Thr246 was positively related with PI3K (r=0.588, P=0.045), AKT (r=0.828, P=0.001) (Fig. 4). The gene discussed is AKT1S1; the disease is gastric cancer.