The results of further correlation analysis also showed that there was a positive correlation between p-PRAS40-Thr246 and p-PI3K and p-ATK levels, suggesting that p-PRAS40-Thr246 can also indicate the activation state of PI3K/AKT signaling pathway in gastric cancer cells, thus reflecting the degree of response of PI3K/AKT signaling pathway to inhibitors. Here, AKT1S1 is linked to gastric cancer.