IL10 and infection: infection seems to be linked to the production of IL-10 in most of cases (Hoerauf et al., 1994; Palanivel et al., 1996; Arcanjo et al., 2015, 2017a,b; Gonzaga et al., 2015, 2017; Geraldo et al., 2016) suggesting that this cytokine promotes infection, which is not restricted to B-1 cells endogenously, but also in relation to other cells, such as macrophages (Arcanjo et al., 2017a).