Figure S4 shows the percentages of cells that were positive for S100A12 in each tissue sample group (normal bladder, adjacent normal bladder tissue, T1-3 stage tumors and G1-3 grade tumors). The data shows normal bladder has the lowest expression of S100A12 and that expression rises with stage and grade. It is clear that the highest expression is present in the normal bladder tissue adjacent to the tumor suggesting immune infiltration by leukocytes (Figure 5). The gene discussed is S100A12; the disease is neoplasm.