DDAH1 and Familial prostate cancer: In the majority of cases where there is a change in DDAH1 expression in tumor samples, it is significantly increased: these include breast cancer, colorectal cancer, lymphoid neoplasm diffuse large B-cell lymphoma, esophageal cancer, ovarian cancer, prostate cancer, rectal adenocarcinoma, stomach cancer, thyroid cancer, and uterine corpus endometrial carcinoma (Figure 2C).