INS and hyperinsulinism: Type 1 (insulin-resistant)diabetes is diagnosed in approximately 10% of all patients with diabetesmellitus and is associated with autoimmune destruction of pancreatic βcells, resulting in the body’s inability to produce insulin.Insulin-independent type 2 diabetes mellitus (90% of all diabetic patients)manifests itself in relative hyperinsulinemia caused by insulin resistance incells [29].