Tumor-derived vesicles were found tosignificantly increase the expression of genes having a verifiedimmunity-regulating function in activated CD4+ T cells, while innaïve cells, gene expression slightly increased only for FAS1, IL-10, andPTGS2, while decreasing for DPP4, CD40LG, and NT5E [82]. This evidence concerns the gene CD4 and neoplasm.