Tumor-derived vesicles often carry both of these enzymes (i.e., they are in theCD73+CD39+ status), which has a negative impact on Tcells in a tumor microenvironment [69].CD73+CD39+ vesicles induce adenosine secretion; they alsoactivate inosine biosynthesis upon longer contact with cells [70]. The gene discussed is NT5E; the disease is neoplasm.