CD8A and neoplasm: When incubatedwith Fas+ T cells, EVs carrying the highly active membrane proteinFasL contribute to cytochrome c release into the cytosol, lossof the mitochondrial membrane potential, caspase activation, and DNAfragmentation in T-cell chromatin [48,50, 51].The coexpression of FasL and TRAIL on the surface ofsecreted tumor-derived vesicles also induces apoptosis in CD8+ Tcells [52].