Thus, a positive or negativeassociation between autoimmune diseases and various HLA alleles can bedetermined through the structural features of the antigen-binding groove of theMHC molecule, which is encoded by a certain allele and is responsible forpeptide binding (particularly, the arrangement of certain amino acids indefinite positions within this groove, such as the positions 11, 71, and 74 inthe MHC β-chain) [8, 16].These MHCs, with point substitutions,vary in their efficiency of binding and presentation of self-peptides[17, 18]. The gene discussed is HLA-C; the disease is autoimmune disease.