Remarkably, RH‐XOS supplementation for 12 weeks in T2DM rats significantly restored insulin‐stimulated AktSer473 phosphorylation in skeletal muscle, which is consistent with the results from a previous in vitro study that reported the activation of Akt phosphorylation of insulin‐resistant C2C12 cells after incubation with inulin (Yun et al., 2009). Here, INS is linked to type 2 diabetes mellitus.