Remarkably, RH‐XOS supplementation for 12 weeks in T2DM rats significantly restored insulin‐stimulated AktSer473 phosphorylation in skeletal muscle, which is consistent with the results from a previous in vitro study that reported the activation of Akt phosphorylation of insulin‐resistant C2C12 cells after incubation with inulin (Yun et al., 2009). This evidence concerns the gene AKT1 and type 2 diabetes mellitus.