For instance, obesity tends to be accompanied by excessive consumption of HFD, and related to a chronic inflammation condition characterized by the increased plasma levels of proinflammatory cytokines such as tumor necrosis factor α (TNF-α), interleukin-6 (IL-6), and interleukin-1 (IL-1). Here, IL6 is linked to obesity due to melanocortin 4 receptor deficiency.