To further delineate the role of FcγRIIB in EBA development, we characterized the antibody response in B6.s wt and B6.s-Fcgr2b−/− mice during the course of the disease to determine whether the lack of FcγRIIB would affect the vWFA2-specific IgG response. This evidence concerns the gene FCGR2B and acquired epidermolysis bullosa.