However, chronic activation of GPER with G1 (400 μg/kg/day) attenuates the adverse effects of monocrotaline (MCT)-induced pulmonary arterial hypertension (PAH) on SERCA2a and the ratio of phosphorylated PLB to total PLB in an OVX model (20). This evidence concerns the gene GPER1 and pulmonary arterial hypertension.