TARDBP and amyotrophic lateral sclerosis: More recent studies have shown that phosphorylated TDP-43 is similarly present in the brain of individuals over 80 years-old that have not been diagnosed with FTLD or ALS, but who often exhibit sights of Alzheimer’s disease (AD) or hippocampal sclerosis (Amador-Ortiz et al., 2007a,b).