LATE has been classified as a form of TDP-43 proteinopathy that impacts adults of advanced age regardless of whether or not they exhibit hippocampal sclerosis; LATE neuropathological change (LATE-NC) is characterized by mislocalized and phosphorylated TDP-43 that mainly affects limbic structures (Nelson et al., 2019). The gene discussed is TARDBP; the disease is proteostasis deficiencies.