ADNP and ADNP-related multiple congenital anomalies - intellectual disability - autism spectrum disorder: In this regard, the human ADNP syndrome patient was shown to be mimicked by the Adnp-haploinsufficient mouse model, implying a strong impact of the Adnp genotype, which included neurodevelopmental delays, as well as cognitive, social, and motor deficits (Hacohen-Kleiman et al., 2018).