ECM and focal adhesion molecules, including PLXDC2, PDGFRB, FSTL1, TIMP2, FAP, SPARC, AEBP1, NOX4, and FBLN2 are known to regulate macrophage mobilization into tumor tissues19,20,48–50, and are associated with TAM51–53. This evidence concerns the gene AEBP1 and neoplasm.