Noteworthy, crossing this Rab5 model with APP-models of AD accelerated Aβ accumulation and cholinergic neurodegeneration, suggesting that APP mutation/elevation may change the effect of Rab5 activation on Aβ production (Nixon, R. A. Rab5 hyper-activation and aberrant endosomal signaling: a new mouse model of early stage Alzheimer’s Disease. Here, RAB5A is linked to Alzheimer disease.