In contrast, treatment of cells with the NF-κB inhibitor BAY 11–7082 strongly reduced the ability of CD95 to activate STAT1 in CD95 stimulated MCF-7 cells (Fig. 3B), and two other breast cancer cell lines we recently showed activate STAT1 in response to CD95 stimulation (Fig. 3C)29. This evidence concerns the gene NFKB1 and breast carcinoma.