FAS and squamous cell carcinoma: Because we also demonstrated similar effects of CD95 stimulation and IFN-I treatment in a squamous cell carcinoma cell line29 and we and others showed that a IFN-I gene signature is linked to increased treatment resistance29,36,37, we conclude that the discrepancy between our data and the previous work on colon cancer is not due to differences between different cancers or cell lines but is more likely a reflection of the differences in the response by cells to DNA demethylating reagents and CD95 stimulation.