LGR5 and colorectal carcinoma: CSC markers identified in CRC, include CD44, leucine-rich repeat-containing G-protein-coupled receptor 5 (LGR5), c-Myc, ABCG2, CD133, ALDH1A1, epithelial cell adhesion molecule (EpCAM) and doublecortin-like kinase-1 (DCLK1)7. CSCs rely on classic signaling pathways for growth such as the Notch signaling that plays an important role in transformation and CSC self-renewal8.