This signalling pathway is essential for normal physiological function, including regulating cell differentiation, proliferation, and apoptosis30 Previous data suggested aberrant IGF signalling has been implicated in various cancers, including breast cancer31,32 and human colon cancer33 and infinite proliferation and division of cancer cells were accomplished by activating IGF1R via the AKT signalling pathway34. The gene discussed is AKT1; the disease is cancer.