IGFBP5 and neoplasm: When combining LAT1 and IGFBP-5 expression, high LAT1/high IGFBP-5 score correlated with the advanced pT stage (P = 0.0001), advanced tumour grade (P = 0.0026), high LDH (P = 0.0064), and high NLR (P = 0.0070) (Table 4).