We next investigated whether, as with CaSki P3 model, up-regulation of HSP90A is reproduced in other immune-edited tumor models, TC-1 P3 and MDA-MB231 P3, which were generated from its immune-susceptible parental cell line (TC-1 and MDA-MB231, respectively) through three rounds of in vivo selection by cognate CTLs, respectively25,26. This evidence concerns the gene HSP90AA1 and neoplasm.