In addition, knockdown of HSP90AA1 in P3 cells decreased in vitro sphere-forming capacity (Fig. 1f and Supplementary Fig. 4) and reduced tumor-initiating property when transplanted into NOD/SCID mice (Table 1), indicating that HSP90A is important for maintenance of CSC-like properties in immune-edited P3 tumor cells. Here, HSP90AA1 is linked to neoplasm.