As shown in Supplementary Figs. 2K-R and 3D and E, except for increased percentages of splenic CD4+ T cells (Supplementary Fig. 2P), reduced percentages of CD4+IFN-γ+ T cells (Supplementary Fig. 2R) and reduced percentages of CD11b+Gr-1− myeloid cell in the spleens (Supplementary Fig. 3E) of Cbs+/− mice, there were no significant differences in percentages of myeloid or CD4+ T cells in the lungs and spleens of Cbs+/− and WT mice at 3 weeks post infection. The gene discussed is CBS; the disease is infection.