While scoring the individual samples on LV2 revealed that STZ-induced T1D pathology significantly upregulated that cytokine profile compared to APP/PS1 pathology, more interestingly, scoring samples on LV1 revealed that APP/PS1 with STZ-induced T1D pathology robustly increased scores on the LV1 cytokine profile compared to either pathology alone (Fig. 1d). Here, APP is linked to type 1 diabetes mellitus.