APP and type 2 diabetes mellitus: We studied the APP/PS1 model alone or in combination with either a prediabetic state induced by a high-fat diet (APP/PS1-HFD), a well-established T1D induced by streptozotocin (APP/PS1-STZ), or a well-established T2D induced by crossing APP/PS1 mice with the classic T2D mouse model db/db (APP/PS1xdb/db).