Given that T2D diabetes, as modeled by db/db and HFD mice, amplified brain Aβ levels (Additional file 1: Figure S1B) and enhanced pro-inflammatory cytokine production (Figs. 2 and 3), we next hypothesized that peripheral plasma levels would correlate with brain cytokine expression in APP/PS1xdb/db mice. The gene discussed is APP; the disease is type 2 diabetes mellitus.