APP and type 2 diabetes mellitus: An overall increase in microglia burden was observed in SP-free areas within T2D mice [F(7,42)=4.68, **p = 0.001 vs. control and APP/PS1] (Additional file 1: Figure S1C and D) whereas no differences were detected in proximity to SP [F(7,21) = 1.98, p = 0.147] (Additional file 1: Figure S1C and D).