Examples include RRS1 (q value = 6.16E−09), which encodes for the ribosomal biogenesis protein homolog that promotes angiogenesis and cellular proliferation, but suppresses apoptosis [42]; KRTAP5-5 (q value = 4.89E−08), which encodes for keratin-associated protein 5-5, a protein that plays important roles in cytoskeletal function and facilitates various malignant behaviors that include cellular motility and vascular invasion [43]; and ALDOB (q value = 2.64E−07), which encodes for aldolase B, an enzyme that promotes metastatic cancer-associated metabolic reprogramming [44]. This evidence concerns the gene RRS1 and metastatic malignant neoplasm.