The area under the curve (AUC) for the ROC curve of the test with exo-AnxA2 levels in serum samples of breast cancer patients as the disease indicator was 0.9484 ± 0.01327 (95% CI = 0.9223–0.9744, P < 0.0001; Fig. 7a). This evidence concerns the gene ANXA2 and breast cancer.