Taken together, the activation of PlGF and CRP in at-risk children (A/ND) in the current study is intriguing and warrants further follow-up to understand whether alterations in the activity of cytokine networks, beyond being associated with neurobehavioral phenotype, may also be suggestive of low-grade inflammation that may be predictive of vulnerability to later life diseases/disorders such as cardiovascular disease and mental health problems. This evidence concerns the gene PGF and cardiovascular disorder.