AKT1 and hyperinsulinemic hypoglycemia, familial, 4: All above results showed that inhibition of PI3K/Akt pathway could aggravate the harmful effect induced by hypoxia and nutrition deficiency condition while activation of PI3K/Akt pathway could meliorate the inhibiting effect, which demonstrated that PI3K/Akt signal pathway has protective effects on hNP-MSCs against hypoxia and nutrition deficiency.