Higher phosphorylation level of p38/MAPK (p-p38/MAPK) was observed in circ-MAPK4 silenced glioma cells compared with control cells, while total protein levels of p38, ERK, JNK, CREB and the phosphorylation level of ERK remained unchanged (Fig. 3f). The gene discussed is MAPK8; the disease is central nervous system cancer.