Isoflavones mainly contain DZN and genistein, which are present in soybeans and other Fabaceae. Because of structural similarities between isoflavones and endogenous estrogens, isoflavones and their metabolites are able to bind estrogen receptors and exert hormonal effects, including anti-oxidative, anti-inflammatory [43], and anti-tumor cell proliferation [44]. This evidence concerns the gene ESR1 and neoplasm.