Vascular dysfunction related to obesity seems to be derived from several changes in adipose tissue, leading to a chronic inflammatory state and dysregulation of adipocyte-derived factors and consequently, an imbalance between the vasoprotective (e.g., NO) and the vascular hazardous factors (e.g., endothelin-1) [41,42]. The gene discussed is EDN1; the disease is obesity due to melanocortin 4 receptor deficiency.