However, in the 200 mg/kg YES-10/ischemia group, the cytoplasm of GFAP immunoreactive astrocytes was lesser hypertrophied compared to those in the other ischemia groups (Figure 4H), and their ROD was significantly lower (about 109% versus vehicle/sham group) than that in the vehicle/ischemia group (Figure 4I). Here, GFAP is linked to ischemia.