SLC30A3 and cerebral amyloid angiopathy: We have demonstrated that a reduction in the cerebral zinc content by genetic ablation of zinc transporter 3 (ZnT3), which controls the sequestration of zinc into synaptic vesicles, attenuates Aβ deposition and cerebral amyloid angiopathy (CAA) in Tg2576 mice overexpressing human APP [18,19].