A study by Laso-García and colleagues in mice model of multiple sclerosis (MS), a chronic autoimmune disease affected central nervous system and causing demyelization of axons [78], showed that EVs derived from ADSCs enhanced motor function in mice, modulated neuroinflammation by decreasing levels of pro- and anti-inflammatory cytokines such as granulocyte-macrophage colony-stimulating factor (GM-CSF), IFNγ, TNFα, IL-1β, IL-2, IL-4, IL-5, IL-6, IL-12p70, IL-13, and IL-18, as well as reduced brain atrophy [50]. Here, CSF2 is linked to multiple sclerosis.