GPX1 and Hepatic failure: Another study conducted by Yan et al. focusing on both in vivo (murine model of acute toxicant-induced liver injury) and in vitro (human cell lines: fetal hepatocyte (L02) and lung fibroblasts (HFL1)) models, has shown that glutathione peroxidase 1 (GPX1) carried by UC-MSC-EVs protected from liver failure caused by carbon tetrachloride (CCl4) administration [59], which suggested anti-oxidative effect of EVs.