Notably, TNT signaling between B-cell precursor ALL (B-ALL) and surrounding BMSC cells induces the secretion of pro-survival cytokines including IP10/CXCL10, IL-8, and MCP-1/CCL2, and protects leukemic cells from chemotherapeutic drugs [177,180]. The gene discussed is CXCL8; the disease is acute lymphoblastic leukemia.