PPARGC1A and acute myeloid leukemia: While the donation of functional mitochondria had no apparent adverse effect on the metabolic health of BMSC, AML blasts develop an increase in mitochondrial mass which is further enhanced by increased mitochondrial biogenesis in BMSC through peroxisome proliferator-activated receptor gamma coactivator 1-alpha (PGC-1α), which is essential for sustained mitochondrial transfer to AML cells [179].