Of note, in vitro studies using OCI-AML3 and OCIM2 AML cell lines suggest that the higher expression of Cx43 in OCI-AML3 cells acts as a tumor promoter, which exerts its effect by promoting the exchange of growth factors; or by facilitating malignant cell proliferation and survival signal [156]. The gene discussed is GJA1; the disease is acute myeloid leukemia.