In contrast, others have reported that reduced Cx43 expression or deterioration of GJIC in BMSC is associated with leukemogenesis, while the upregulation of Cx43 GJIC in BMSC after chemotherapy or transfection with the Cx43 gene induces caspase 3 and 7 mediated apoptosis, and enhances the efficacy of therapies in hematologic malignancies [157,158,159,160,161]. The gene discussed is GJA1; the disease is hematologic disorder.