In addition, study on interaction between G-quadruplex adopted by r(G4C2)8 and porphyrin TMPyP4 has shown that TMPyP4 distorts the formation of G-quadruplex, which prevents binding of proteins associated with ALS such as hnRNPA1 [32]. The gene discussed is HNRNPA1; the disease is amyotrophic lateral sclerosis.