While no KEGG pathway was identified for the 19 D4 mHSC-specific EV proteins, most of the these pathways were, respectively, prominent for either the 27 proteins that were shared between D4 and P1 mHSC EVs (regulation of actin cytoskeleton, leucocyte transendothelial migration, systemic lupus erythematosus, alcoholism) (Figure 6B) or the P1 mHSC EV-specific proteins (focal adhesion, PI3K-Akt signaling, proteasome, ECM-interactions, pathways in cancer) (Figure 6C). Here, AKT1 is linked to alcohol dependence.