Importantly, EV FN1 may also directly participate in downstream pro-fibrogenic actions of HSC EVs in light of recent studies showing, firstly, that FN1 in cancer cell microvesicles mediates their ability to confer transformation characteristics on fibroblasts and epithelial cells [58] and, secondly, that exosomal FN1 mediates the mitogenic activity of exosomes from mesenchymal stem cells [59]. Here, FN1 is linked to cancer.