Some of the same or related components were evident for LX-2 hHSC EV-specific proteins (regulation of cytoskeleton, pathways in cancer, ribosome, PI3k-AKT signaling, proteoglycans in cancer, phagosome, focal adhesion, cell adhesion molecules, alcoholism) (Figure 9C) or for P1 mHSC EV-specific proteins (proteasome, ECM-receptor interactions) (Figure 9D) but the remaining components in these groups were quite dissimilar and diverged from those typically noted above. Here, AKT1 is linked to cancer.