AKT1 and cancer: For example, the top 20 KEGG pathways for the complete LX-2 hHSC EV proteome (Figure 9A) showed substantial overlap with the pathways for the P1 mHSC EV proteome (Figure 6A) and included focal adhesion, PI3K-Akt signaling, regulation of actin cytoskeleton, pathways in cancer, proteoglycans in cancer, ribosome, phagosome, leukocyte transendothelial migration, protein processing in the ER and carbon metabolism.