In lung cancer, Cav-1 is found to act on multiple downstream effectors, such as epidermal growth factor receptor (EGFR) [26], extracellular regulated protein kinases (ERK) [27], focal adhesion kinase (FAK) [28] and protein kinase B (AKT) [28], to mediate key aspects of cancer progression. This evidence concerns the gene AKT1 and lung cancer.