A decrease in SERCA2 expression [34,35] and SERCA3 expression [36,37,38] has been observed in several different cancer cell lines and tumor samples, as well as alterations in the genes coding for SERCA2 and SERCA3 have been shown in samples from cancer patients [39,40,41], indicating that transport of calcium from the cytosol to ER could be reduced in cancer cells. Here, ATP2A3 is linked to cancer.