To confirm the role of tumor-secreted IL-6 and TGF-β in modulating CBs expression, HPFs were treated with conditioned media from DU-145 cells in the presence of and without blocking antibodies for IL-6 (α-IL-6) and a selective inhibitor of TGF-β receptor 1 (A8301). This evidence concerns the gene TGFB1 and neoplasm.