Overall, the general picture of this study (summarized in Figure 12), in middle aged rodent model, shows that the responses to the HFF diet are similar in adipose tissue and brain tissue for several (UCP2, PPAR-α, PGC-1α, TNF-α, adiponectin), but not all the measured parameters (i.e., insulin resistance onset in e-WAT but not brain, or lipocalin and haptoglobin, whose level is not modified in brain or e-WAT, respectively). Here, PPARGC1A is linked to Insulin resistance.