It has been shown that eGFR <60 mL/min/1.73 m2 is associated with increased risk for all-cause and cardiovascular mortality, progressive chronic kidney disease (CKD), end-stage renal disease, and acute kidney injury even with an albumin-to-creatinine ratio (ACR) <30 mg/g [13]. This evidence concerns the gene ALB and stage 5 chronic kidney disease.