AKT1 and malignant colon neoplasm: Murrayazoline and O-methylmurrayamine were shown to induce the downregulation of Akt/mTOR, suggesting downstream targeting of the cell survival pathway and an ability to potentiate the antitumor activity of D.L. Dexter (DLD-1) colon cancer cells; interestingly, this inhibition of the Akt/mTOR pathway could possibly activate the intrinsic apoptotic program [86].