In supporting this, a study from patients with vulva intraepithelial neoplasia (VIN) (n = 32) treated with ALA-PDT showed that VIN that display loss of MHC class I (n = 9) failed to respond to the treatment, whereas the responders exhibited significantly higher CD8+ T cell infiltration than non-responders [71]. The gene discussed is CD8A; the disease is vulvar intraepithelial neoplasia.