-Increased of peripheral granulocyte at 1 and 2 weeks-increase of peripheral monocyte at 1 week-Increased levels of IL-6 in serum at 1 week-Increased number of peripheral Treg at 2 weeks-Inhibited immunosuppressive function of peripheral Treg at 2 w-No significant change of peripheral lymphocytenumbers or systemic CD4+ T cell numbers at 1 week-No significant changes of tumor-infiltrating Treg at 1 and 2 weeks. This evidence concerns the gene CD4 and neoplasm.