CD4 and neoplasm: -Inhibited tumor metastases-Reduced growth of tumor re-challenge-CD4+CD8+ T cells accumulate in tumor, being mostly central memory T cells (CD44hiCD62Lhi) -No significant change of CD3+ T cells in spleen-Elevated serum levels of TNF-α and IFN-ƴ-Restore immune balance to healthy state and prolong relapse-free survival