INS and diabetes mellitus: This strong genetic association changed little even after multivariate adjustment (p = 3.90 × 10−15 in the unadjusted additive model; p = 2.19 × 10−14 in the model adjusted for sex, age, and diabetes and p = 9.81 × 10−14, in the model adjusted for sex, age, diabetes, BMI, medications (including antihypertensive drugs, lipid lowering drugs, and insulin and oral antidiabetic medication), smoking, physical activity, and adherence to the Mediterranean diet.