INS and diabetes mellitus: This strong genetic association did not vary significantly even after multivariate association (p = 7.02 × 10−15 in the unadjusted model; p = 3.35 × 10−14 in the model adjusted for sex, age, and diabetes and p = 8.90 × 10−14, in the model adjusted for sex, age, diabetes, BMI, medications (including antihypertensive drugs, lipid lowering drugs, and insulin and oral antidiabetic medication), smoking, physical activity, and adherence to the Mediterranean diet.