Among the major tumor-infiltrating immune effector cells that can be identified by CIBERSORT, including CD8 T cell, CD4T memory activated, CD4 T cell memory resting, macrophage M0, macrophage M1, and macrophage M2, the CD8 T cell and macrophage M1 fractions positively correlate with responsiveness to anti-CTLA-4, while the CD4 T cell memory resting fraction shows a negative correlation (Figure 5a). This evidence concerns the gene CD8A and neoplasm.