SORL1 and Alzheimer disease: Ghanbari et al. demonstrated not only that miRNA-1229 is implicated in AD by regulating the translation of SORL1, but also that the pre-miRNA-1229 variant rs2291418 (cytosine to uracil in the RNA, indicated by arrows in Figure 1), which results in increased levels of mature miRNA-1229-3p, is associated with AD [38].