The authors of this study also demonstrated that highly metastatic breast carcinoma cell lines and human breast tumor biopsy samples present lower expression of Siva1 and decreased phospho-Ser16-stathmin levels, as compared to low metastatic breast tumor cell lines and normal breast tissues, consistent with the anti-metastatic role of the Siva1/CaMK-II system. The gene discussed is SIVA1; the disease is breast carcinoma.