Moreover, it has been established that shifting melanoma cell migration from an amoeboid mode, primarily mediated by Rho/ROCK signaling and characterized by high actomyosin contractility, to a mesenchymal-type mode, mediated by Rac1/WAVE2 signaling and characterized by low actomyosin contractility and high proteolytic activity, is an interconvertible mutually exclusive process regulated by a Rac1 activation/inactivation cycle [198]. Here, RAC1 is linked to melanoma.