Consistent with this, downregulation of eEF2K with siRNA or rottlerin in a highly metastatic ductal pancreatic carcinoma cell line inhibits invasiveness and EMT by decreasing the expression of transglutaminase as well as integrin-β1, urokinase receptor (uPAR), and matrix metalloprotease-2 (MMP-2), and decreasing the activity of c-Src, while overexpression of eEF2K enhanced the migratory and invasive capacity of the tumor cells [262]. The gene discussed is EEF2K; the disease is pancreatic ductal adenocarcinoma.