In contrast to what happens in other cells, stimulation of NHE1 by angiotensin-II, due to cytosolic Ca2+ increase and subsequent CaM activation, induced the repression of melanoma cell migration, a process that was mirrored by losartan, an inhibitor of the angiotensin-II receptor type 1 (AT1) while promoting the adhesion and invasiveness of these tumor cells [305]. This evidence concerns the gene CALM2 and melanoma.