PTK2 and neoplasm: Thus, the inhibition of mtCaMK-II or MCU inhibits PDGF-induced VSMC migration and the translocation of mitochondria to the leading migratory edge of the cell, decreasing therefore FAK phosphorylation, focal adhesion turnover, and the necessary remodeling of the cytoskeleton, processes required for cell migration [226] and likely occurring as well in tumor cells.