CALM3 and neoplasm: Moreover, the intracellular Ca2+ chelator BAPTA-AM (1,2-bis(2-aminophenoxy)ethane-N,N,N′,N′-tetraacetic acid) and W-7 decreased both the PMA-induced secretion of this extracellular protease and tumor cell migration [83], suggesting a Ca2+-dependent action of CaM in these processes.