SLC9A1 and breast carcinoma: The Na+/H+-exchanger 1 (NHE1) binds Ca2+/CaM at its C-terminal region preventing auto-inhibition, and upregulation of this transport system plays an important role in EMT and metastasis development in triple-negative human breast carcinoma, a process that is inhibited by a specific NHE1 inhibitor [302,303].