In fact, Orai1 is overexpressed in some tumors [11], and downregulation of both STIM1 and Orai1 by siRNA or directly blocking store-operated Ca2+ entry with the drug SKF96365 (1-[2-(4-methoxyphenyl)-2-[3-(4-methoxyphenyl)propoxy]ethyl]imidazole) inhibited tumor cell migration and metastasis development [12,13]. The gene discussed is ORAI1; the disease is neoplasm.