CALM3 and neoplasm: This could be done upon administrating the repressor, which downregulates CaM expression during different phases of the metastatic process, encompassing for example the local infiltration of normal tissues surrounding the primary tumor derived from implanted tumor cells, the transmigration of these cells through blood and lymphatic vessels, the invasion of local lymph nodes, the viability of the circulating tumor cells, and/or the establishment of metastatic foci in colonized distant organs.